Endocrine Abstracts

Introduction: Charles Bonnet syndrome is almost unknown by the endocrinologists. It is composed by visual hallucinations that do not react with the patient contrary to psychiatric hallucinations. The abnormal visions (generally hidden by patients) appear in subjects with an impaired vision of one of both eyes as in the following case:Case report: A man aged 27, was referred for acromegaly secondary to a huge invasive somatolactotrope pituitary adenomas d...

Pomc synthesis and ACTH secretion by the anterior pituitary are controlled by two major, opposing players namely CRH and glucocorticoids. Most studies were performed on the AtT-20 mouse corticotroph tumor cell line or Pomc-transfected cells.Aim: Aim of the present study was to evaluate the effect of CRH and DEX on Pomc expression and ACTH secretion in normal rat corticotropes in vitro.Methods: Rat anteri...

Spermatozoa generate small amounts of O2°- and NO°. Under physiological condition these compounds exist at very low concentration and the formation of peroxynitrite (ONOO−) appears likely. Peroxynitrite reacts rapidly with proteins, lipids and DNA. Moreover, tyrosine nitration is a widely used marker of peroxynitrite. The nitration of protein residues gives rise to 3-nitrotyrosine which represents a protein modification specific for ONOO− formation in ...

Introduction: Several recent studies have reported an increase in the incidence of thyroid cancer during the last decades. The delineation between low-risk and high-risk tumor size is not well defined. The purpose of this study was to evaluate the relationship between the primary tumor size of differentiated thyroid cancer and clinicopathologic data.Methods: We have analysed all records of all patients submitted to thyroidectomy at our hospital between 2...

Introduction: Recent data reveal that in the last 25 years it has been a 2.4 fold increase in thyroid cancer, with concomitant rise in thyroid microcarcinoma cases. The main purpose of this study was to analyse the surgical indications that leads to incidentally noted papillary microcarcinoma diagnosis.Methods: We analysed clinicopathologic data of nineteen cases of incidentally found papillary thyroid microcarcinoma, from 1244 thyroid surgeries realized...

Aim: To study the effectiveness of metformin in treatment of polycystic ovaries syndrome (PCOS) in women of birthing age.Materials and methods: We followed 31 women with PCOS. Mean age of patients was 29.8 years old. All patients were evaluated for hormones levels (LH, FSH, TSH, estradiol, progesterone, testosterone, prolactin, coritsole, free thyroxine, dehydroepiahndrostendione etc.), glucose tolerance test, lipids profile, uterus and ovaries ultrasono...

PCOS (defined by NIH, Rotterdam or AES criteria) is traditionally viewed as an ovarian disorder that appears in adolescence and may lead to metabolic complications in adulthood. Emerging evidence, however, indicates that PCOS is primarily a disorder of adipose-tissue hyperexpansion that may originate in early life, develop across childhood and puberty, and advance into end-stage disease (including ovulatory dysfunction and ovarian androgen excess) by adolescence. Prepubertal m...

Introduction: Adrenal incidentaloma are becoming very frequent. Bilateral adrenocortical adenomas are a rare cause of ACTH-independent Cushing syndrome.Clinical case: A 64-year-old hypertensive woman presented with bilateral adrenal incidentaloma detected on the evaluation as a living kidney donor candidate. She was normotensive (129/87 mmHg) on monotherapy, BMI – 24.8 kg/m2, with no recent weight gain, hirsutism, striae or mood disturban...

Objective: To improve post-operative thyroid surgery practice and to determine if it would be safe to perform thyroid surgery as day surgery. To identify the nature and timings of acute life threatening airway complications, trends in current practice, and gain information on perioperative mortality....

BACKGROUND: Dynamic function tests are needed to diagnose a range of endocrine disorders but often require in-patient investigation. A recent audit of our endocrine service revealed deficiencies that included frequent delay to investigations and cancellation of planned appointments. We developed an Endocrine Nurse Specialist (ENS) post whose role included carrying out endocrine testing in an out-patient setting to assess whether this might improve quality of care for our patie...